The synagogue in Neuwied was consecrated in 1748. It was located at the beginning of Engerser Straße, which was renamed Synagogengasse in 1983.

The Jewish community of Neuwied initially had a prayer room in lower Schlossstraße. As the community grew, plans for the construction of a synagogue began in 1739. Count Friedrich Alexander provided a plot of land in close proximity to the castle and supplied 10 logs, 200 carts of stones, and 100 carts of sand for the construction. On August 13, 1748, the synagogue was solemnly consecrated and was destroyed by the Nazis on the night of the November Pogrom on November 9, 1938.

At the same time, it is meant to remind of the formerly Jewish life and culture in Neuwied, alongside the stumbling stones that have been placed throughout the city.